AroC

• Description: 3-dehydroquinate dehydratase
  
  

Gene name	aroC
Synonyms
Essential	no
Product	3-dehydroquinate dehydratase
Function	biosynthesis of aromatic amino acids
Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp
MW, pI	27 kDa, 4.898
Gene length, protein length	765 bp, 255 aa
Immediate neighbours	serA, rsiX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU23080

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 3-dehydroquinate = 3-dehydroshikimate + H₂O (according to Swiss-Prot)

• Protein family: type-I 3-dehydroquinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1GQN (from Salmonella typhi, 55% identity, 70% similarity) PubMed

• UniProt: P35146

• KEGG entry: [3]

• E.C. number: 4.2.1.10

Expression and regulation

• Operon: aroC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

V Azevedo, A Sorokin, S D Ehrlich, P Serror
The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci.
Mol Microbiol: 1993, 10(2);397-405
[PubMed:7934830] [WorldCat.org] [DOI] (P p)

R J Warburg, I Mahler, D J Tipper, H O Halvorson
Cloning the Bacillus subtilis 168 aroC gene encoding dehydroquinase.
Gene: 1984, 32(1-2);57-66
[PubMed:6442253] [WorldCat.org] [DOI] (P p)