FadM

• Description: fatty acid degradation, similar to proline dehydrogenase
  
  

Gene name	fadM
Synonyms	yusM
Essential	no
Product	unknown
Function	fatty acid degradation
Gene expression levels in SubtiExpress: fadM
Metabolic function and regulation of this protein in SubtiPathways: fadM
MW, pI	34 kDa, 9.377
Gene length, protein length	906 bp, 302 aa
Immediate neighbours	yuzL, yuzM
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of lipids, sporulation/ other

This gene is a member of the following regulons

FadR regulon, SdpR regulon

The gene

Basic information

• Locus tag: BSU32850

Database entries

• BsubCyc: BSU32850

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor (according to Swiss-Prot)

• Protein family: proline dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): PutB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU32850

• Structure:

• UniProt: O32179

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • fadM-fadN-fadA-fadE PubMed

• Expression browser: fadM PubMed

• Sigma factor:

• Regulation:
  • fadM: induced by long-chain fatty acids (FadR) PubMed

• Regulatory mechanism:
  • FadR: transcription repression PubMed
  • SdpR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)