CatR

• Description: MarR/DUF24 family transcription repressor of the catD-catE operon
  
  

Gene name	catR
Synonyms	yvaP
Essential	no
Product	MarR/DUF24 family transcription repressor
Function	resistance against oxidative and electrophile stress
Gene expression levels in SubtiExpress: catR
MW, pI	26 kDa, 9.887
Gene length, protein length	708 bp, 236 aa
Immediate neighbours	yvaO, yvaQ
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The CatR regulon:

catD-catE

The gene

Basic information

• Locus tag: BSU33680

Phenotypes of a mutant

increased resistance to catechol and quinones PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: MarR/DUF24 family transcription repressor of the catD-catE operon PubMed

• Protein family: MarR/DUF24 family

• Paralogous protein(s): YodB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of catD-catE) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32238

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: catR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Reviews

Antelmann H, Helmann JD.
Thiol-based redox switches and gene regulation.
Antioxid Redox Signal. 2011,14:1049-63.
PubMed

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)

Original Articles

Bui Khanh Chi, Kazuo Kobayashi, Dirk Albrecht, Michael Hecker, Haike Antelmann
The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis.
J Bacteriol: 2010, 192(18);4571-81
[PubMed:20639328] [WorldCat.org] [DOI] (I p)