Cdd

• Description: cytidine deaminase
  
  

Gene name	cdd
Synonyms
Essential	no
Product	cytidine deaminase
Function	pyrimidine interconversion
Gene expression levels in SubtiExpress: cdd
Metabolic function and regulation of this protein in SubtiPathways: Nucleoside catabolism, Nucleotides (regulation)
MW, pI	14 kDa, 4.7
Gene length, protein length	408 bp, 136 aa
Immediate neighbours	era, dgkA
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

nucleotide metabolism/ other

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU25300

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cytidine + H₂O = uridine + NH₃ (according to Swiss-Prot)

• Protein family: cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1JTK (complex with inhibitor), 1UWZ (with Arg56Ala substitution)

• UniProt: P19079

• KEGG entry: [3]

• E.C. number: 3.5.4.5

Expression and regulation

• Operon: cdd-era (according to DBTBS)

• Expression browser: cdd PubMed

• Sigma factor: SigA PubMed, SigB PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

N Mejlhede, J F Atkins, J Neuhard
Ribosomal -1 frameshifting during decoding of Bacillus subtilis cdd occurs at the sequence CGA AAG.
J Bacteriol: 1999, 181(9);2930-7
[PubMed:10217788] [WorldCat.org] [DOI] (P p)

B H Song, J Neuhard
Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.
Mol Gen Genet: 1989, 216(2-3);462-8
[PubMed:2526291] [WorldCat.org] [DOI] (P p)

P Z Wang, R H Doi
Overlapping promoters transcribed by bacillus subtilis sigma 55 and sigma 37 RNA polymerase holoenzymes during growth and stationary phases.
J Biol Chem: 1984, 259(13);8619-25
[PubMed:6330116] [WorldCat.org] (P p)