ManA

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  • Description: mannose-6-phosphate isomerase, required for proper cell wall synthesis

Gene name manA
Synonyms yjdE
Essential no
Product mannose-6-phosphate isomerase
Function mannose utilization
Gene expression levels in SubtiExpress: manA
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 35 kDa, 5.279
Gene length, protein length 945 bp, 315 aa
Immediate neighbours manP, yjdF
Sequences Protein DNA Advanced_DNA
Genetic context
ManA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ManA expression.png



















Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

ManR regulon

The gene

Basic information

  • Locus tag: BSU12020

Phenotypes of a mutant

  • cells lose the characteristic rod shape typical of wild type B. subtilis cells and instead appear as elongated spheres, which are significantly larger than normal PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced by mannose (ManR) PubMed
    • repressed by glucose (ManR) PubMed
    • strongly induced in response to glucose starvation in M9 medium PubMed
  • Regulatory mechanism:
    • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed