RsbV

Gene name	rsbV
Synonyms
Essential	no
Product	anti-anti-SigB
Function	control of SigB activity
Gene expression levels in SubtiExpress: rsbV
Interactions involving this protein in SubtInteract: RsbV
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	11 kDa, 4.698
Gene length, protein length	327 bp, 109 aa
Immediate neighbours	rsbU, rsbW
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, general stress proteins (controlled by SigB), phosphoproteins

This gene is a member of the following regulons

CcpA regulon, SigB regulon

The gene

Basic information

• Locus tag: BSU04710

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: STAS domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-52 AND Ser-56 by RsbW PubMed, PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsbU-RsbV PubMed
  • RsbP-RsbV PubMed
  • RsbV-SpoIIAB PubMed
  • RsbV-RsbWPubMed

• Localization:

Database entries

• Structure: 1VC1 (homolog from Thermotoga maritima)

• UniProt: P17903

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sigB-rsbX PubMed
  • rsbV-rsbW-sigB-rsbX PubMed

• Expression browser: rsbV PubMed

• Sigma factor:
  • rsbR: SigA PubMed
  • rsbV: SigB PubMed

• Regulation:
  • rsbV: induced by stress (SigB) PubMed
• rsbV: repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Bill Haldenwang, San Antonio, USA
• Chet Price, Davis, USA homepage

References

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936