SknR

• Description: transcription repressor of the yqaF-yqdA-yqaG-yqaH-yqaI-yqaJ-yqaK-yqaL-yqaM-yqaN operon of the skin element (Xre family)
  
  

Gene name	sknR
Synonyms	yqaE
Essential	no
Product	transcription repressor
Function	control of prophage gene expression
Gene expression levels in SubtiExpress: sknR
MW, pI	13 kDa, 5.42
Gene length, protein length	348 bp, 116 aa
Immediate neighbours	yqaF, yqaD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, Skin element, essential genes

The gene

Basic information

• Locus tag: BSU26350

Phenotypes of a mutant

• essential in the wild type background (due to overexpression of the toxic proteins YqaH and YqaM) PubMed
• no phenotype if deleted with the complete skin element PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds the yqaF promoter region to repress transcription of the yqaF-yqdA-yqaG-yqaH-yqaI-yqaJ-yqaK-yqaL-yqaM-yqzO-yqaN operon PubMed

• Protein family:

• Paralogous protein(s): YonR, Xre

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P45902

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: sknR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Tatsu Kimura, Yukie Amaya, Kazuo Kobayashi, Naotake Ogasawara, Tsutomu Sato
Repression of sigK intervening (skin) element gene expression by the CI-like protein SknR and effect of SknR depletion on growth of Bacillus subtilis cells.
J Bacteriol: 2010, 192(23);6209-16
[PubMed:20889742] [WorldCat.org] [DOI] (I p)