MurQ

• Description: similar to E. coli MurQ (etherase, cleaves lactate from N-acetylmuramic acid)
  
  

Gene name	murQ
Synonyms	ybbI
Essential	no
Product	putative etherase
Function	cell wall turnover
Metabolic function and regulation of this protein in SubtiPathways: Murein recycling
MW, pI	32 kDa, 5.404
Gene length, protein length	912 bp, 304 aa
Immediate neighbours	murR, ybbJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall degradation/ turnover, utilization of specific carbon sources, phosphoproteins

The gene

Basic information

• Locus tag: BSU01700

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: N-acetylmuramic acid 6-phosphate + H₂O = N-acetyl-D-glucosamine 6-phosphate + D-lactate (according to Swiss-Prot)

• Protein family: SIS domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-2 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: Q45582

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: murQ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Silke Litzinger, Amanda Duckworth, Katja Nitzsche, Christian Risinger, Valentin Wittmann, Christoph Mayer
Muropeptide rescue in Bacillus subtilis involves sequential hydrolysis by beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase.
J Bacteriol: 2010, 192(12);3132-43
[PubMed:20400549] [WorldCat.org] [DOI] (I p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)