GcvH

• Description: glycine cleavage system protein H, 2-oxo acid dehydrogenase, lipoyl-binding site
  
  

Gene name	gcvH
Synonyms	yusH
Essential	no
Product	glycine cleavage system protein H
Function	glycine utilization
MW, pI	14 kDa, 3.888
Gene length, protein length	381 bp, 127 aa
Immediate neighbours	yusG, yusI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of amino acids, Biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU32800

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: gcvH family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): lipoic acid, lipoylated by LipM PubMed

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32174

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Quin H Christensen, Natalia Martin, Maria C Mansilla, Diego de Mendoza, John E Cronan
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
Mol Microbiol: 2011, 80(2);350-63
[PubMed:21338421] [WorldCat.org] [DOI] (I p)

Quin H Christensen, John E Cronan
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases.
Biochemistry: 2010, 49(46);10024-36
[PubMed:20882995] [WorldCat.org] [DOI] (I p)