GpsA

• Description: glycerol-3-phosphate dehydrogenase (NAD)
  
  

Gene name	gpsA
Synonyms
Essential	yes PubMed
Product	glycerol-3-phosphate dehydrogenase (NAD)
Function	biosynthesis of phospholipids
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	37 kDa, 6.231
Gene length, protein length	1035 bp, 345 aa
Immediate neighbours	yphE, yphC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of lipids, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU22830

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: sn-glycerol 3-phosphate + NAD(P)⁺ = glycerone phosphate + NAD(P)H (according to Swiss-Prot)

• Protein family: NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 3K96 (from Coxiella burnetii RSA 493, 37% identity, 59% similarity)

• UniProt: P46919

• KEGG entry: [2]

• E.C. number: 1.1.1.94

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

H R Morbidoni, D de Mendoza, J E Cronan
Synthesis of sn-glycerol 3-phosphate, a key precursor of membrane lipids, in Bacillus subtilis.
J Bacteriol: 1995, 177(20);5899-905
[PubMed:7592341] [WorldCat.org] [DOI] (P p)