SigL

• Description: The sigma-54 and RNA polymerase serve as the receptor for receipt of the melting signal from the remotely bound activator protein levR for the expression of the levanase operon. It is important for the survival in a cold environment
  
  

Gene name	sigL
Synonyms
Essential	no
Product	RNA polymerase sigma-54 factor (sigma-L)
Function	involved in utilization of arginine and ornithine and transport of fructose
MW, pI	49,5 kDa, 7.79
Gene length, protein length	1308 bp, 436 amino acids
Immediate neighbours	yvfG, yvfH
Gene sequence (+200bp)	Protein sequence
Genetic context File:GenE context.gif

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: sigma-54 factor family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • DNA binding domain (H-T-H motif) (324–343)
  • pron box domain (413–421)
  • 3 x Compositional bias domain (6–21),(32–53),(112–136)

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: SigL-RpoB-RpoC

• Localization:

Database entries

• Structure:

• Swiss prot entry: [3]

• KEGG entry: [4]

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: neg. regulated by CcpA

• Regulatory mechanism:

• Additional information:

Labs working on this gene/protein

Michel Debarbouille, Pasteur Institute, Paris, France Homepage

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed