Btr
- Description: transcription activator (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon
Gene name | btr |
Synonyms | ybbB, yzbC |
Essential | no |
Product | transcription activator (AraC family) |
Function | regulation of iron acquisition |
Metabolic function and regulation of this protein in SubtiPathways: Stress | |
MW, pI | 60 kDa, 6.433 |
Gene length, protein length | 1587 bp, 529 aa |
Immediate neighbours | feuA, ybbC |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU01640
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
Categories containing this gene/protein
acquisition of iron, iron metabolism, transcription factors and their control
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription activation of the feuA-feuB-feuC-ybbA operon in the presence of bacillibactin or enterobactin PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): enterobactin, bacillibactin (co-activators) PubMed
- Effectors of protein activity: enterobactin, bacillibactin (co-activators) PubMed
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P40408
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: btr PubMed
- Additional information: the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ahmed Gaballa, John D Helmann
Substrate induction of siderophore transport in Bacillus subtilis mediated by a novel one-component regulator.
Mol Microbiol: 2007, 66(1);164-73
[PubMed:17725565]
[WorldCat.org]
[DOI]
(P p)
G Hambraeus, C von Wachenfeldt, L Hederstedt
Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs.
Mol Genet Genomics: 2003, 269(5);706-14
[PubMed:12884008]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)