CwlP

• Description: cell wall hydrolase of the SP-beta prophage region,
  
  

Gene name	cwlP
Synonyms	yomI
Essential	no
Product	cell wall hydrolase
Function	cell wall turnover
MW, pI	252 kDa, 8.268
Gene length, protein length	6855 bp, 2285 aa
Immediate neighbours	yomJ, yomH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU21350

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: hydrolyzes the peptidoglycan and cell wall of B. subtilis PubMed

• Protein family: FPP/GGPP synthetase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: contains soluble lytic transglycosylase (SLT) and peptidase M23 domains PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O31976

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

I Putu Sudiarta, Tatsuya Fukushima, Junichi Sekiguchi
Bacillus subtilis CwlP of the SP-{beta} prophage has two novel peptidoglycan hydrolase domains, muramidase and cross-linkage digesting DD-endopeptidase.
J Biol Chem: 2010, 285(53);41232-43
[PubMed:20980266] [WorldCat.org] [DOI] (I p)