CcpA
- Description: Carbon catabolite control protein A, involved in glucose regulation of many genes; represses catabolic genes and activates genes involved in excretion of excess carbon
| Gene name | ccpA |
| Synonyms | graR, alsA, amyR |
| Essential | no |
| Product | transcriptional regulator |
| Function | mediates carbon catabolite repression (CCR) |
| MW, pI | 36,8 kDa, 5.06 |
| Gene length, protein length | 1002 bp, 334 amino acids |
| Immediate neighbours | aroA, motP |
| Gene sequence (+200bp) | Protein sequence |
| Genetic context File:GenE context.gif | |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Loss of carbon catabolite repression. Loss of PTS-dependent sugar transport due to excessive phosphorylation of PtsH by HPrK. The mutant is unable to grow on a minimal medium with glucose and ammonium as the only sources of carbon and nitrogen, respectively.
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcriptional regulator of carbon catabolite repression (CCR)
- Protein family: LacI family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- HTH lacI-type Domain (1 – 58)
- DNA binding Domain (6 – 25)
- Modification:
- Cofactor(s): HPr-Ser46-P, Crh-Ser-46-P
- Effectors of protein activity:glucose-6-phosphate, fructose-1,6-bisphosphate Pubmed
- Localization:
Database entries
- Swiss prot entry: [3]
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
Labs working on this gene/protein
Wolfgang Hillen, Erlangen University, Germany Homepage
Richard Brennan, Houston, Texas, USA Homepage
Milton H. Saier, University of California at San Diego, USA Homepage
Yasutaro Fujita, University of Fukuyama, Japan
Jörg Stülke, University of Göttingen, Germany Homepage
