Cytochrome P450 family
The cytochrome P450 superfamily (officially abbreviated as CYP) is a large and diverse group of enzymes. The function of most CYP enzymes is to catalyze the oxidation of organic substances. The substrates of CYP enzymes include metabolic intermediates such as lipids and steroidal hormones, as well as xenobiotic substances such as drugs and other toxic chemicals
B. subtilis encodes eight cytochromes P450:
- BioI (CYP107H1)
- CypA (CYP107J1)
- CypC (CYP152A1)
- CypX (CYP134A1)
- PksS (CYP107K1)
- YetO (CYP102A2)
- YjiB (CYP109B1)
- YrhJ (CYP102A3)
Relevant reviews
Toshiki Furuya, Daisuke Shibata, Kuniki Kino
Phylogenetic analysis of Bacillus P450 monooxygenases and evaluation of their activity towards steroids.
Steroids: 2009, 74(12);906-12
[PubMed:19559718]
[WorldCat.org]
[DOI]
(I p)
D R Nelson
Cytochrome P450 and the individuality of species.
Arch Biochem Biophys: 1999, 369(1);1-10
[PubMed:10462435]
[WorldCat.org]
[DOI]
(P p)
