YvrHb

• Description: sensor kinase of the YvrG-YvrHb two-component system
  
  

Gene name	yvrG
Synonyms
Essential	no
Product	two-component sensor histidine kinase
Function	regulation cell surface maintenance
MW, pI	66 kDa, 9.518
Gene length, protein length	1719 bp, 573 aa
Immediate neighbours	yvrE, yvrHb
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag:

Phenotypes of a mutant

unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin) PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine (according to Swiss-Prot) phosphorylation of the YvrHb response regulator PubMed

• Protein family:

• Paralogous protein(s): CssS, YkoH, KinE, YclK

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YvrG-YvrHb PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: O34989

• KEGG entry: BSU33210

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Serizawa M, Kodama K, Yamamoto H, Kobayashi K, Ogasawara N, Sekiguchi J. (2005) Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses. Biosci. Biotechnol. Biochem. 69: 2155-2169. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed