LutC

• Description: lactate catabolic enzyme
  
  

Gene name	lutC
Synonyms	yvbY
Essential	no
Product	unknown
Function	utilization of lactate
MW, pI	26 kDa, 5.157
Gene length, protein length	720 bp, 240 aa
Immediate neighbours	yvbX, lutB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Phenotypes of a mutant

no growth with lactate as the single carbon source PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: oxidation of lactate to pyruvate PubMed

• Protein family: UPF0707 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry: O32259

• KEGG entry: BSU34030

• E.C. number:

Expression and regulation

• Operon: lutA-lutB-lutC PubMed

• Sigma factor:

• Regulation: induction by lactate PubMed

• Regulatory mechanism: dual repression by LutR (inducer lactate) and SinR PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

References

1. Chai Y, Kolter R, Losick R. (2009) A WIDELY CONSERVED GENE CLUSTER REQUIRED FOR LACTATE UTILIZATION IN BACILLUS SUBTILIS AND ITS INVOLVEMENT IN BIOFILM FORMATION. J Bacteriol. Feb 6. Epub ahead of print PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed