MaeA
- Description: malic enzyme
| Gene name | maeA |
| Synonyms | ywkA |
| Essential | no |
| Product | NAD-dependent malate dehydrogenase |
| Function | malate utilization |
| MW, pI | 63 kDa, 4.883 |
| Gene length, protein length | 1746 bp, 582 aa |
| Immediate neighbours | ywkB, tdk |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: malate --> pyruvate
- Protein family:
- Paralogous protein(s): MalS
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P45868
- KEGG entry: [3]
- E.C. number: 1.1.1.38
Additional information
Expression and regulation
- Sigma factor: SigA
- Regulation: induced by malate (MalR)
- Regulatory mechanism: MalR: transcription activation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France
Your additional remarks
References
- Doan, T., P. Servant, S. Tojo, H. Yamaguchi, G. Lerondel, K. Yoshida, Y. Fujita, and S. Aymerich. 2003. The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate. Microbiology 149: 2331-2343. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
