TuaB

• Description: polymer export
  
  

Gene name	tuaB
Synonyms	yvhB
Essential	no
Product	unknown
Function	biosynthesis of teichuronic acid
Gene expression levels in SubtiExpress: tuaB
MW, pI	53 kDa, 9.984
Gene length, protein length	1449 bp, 483 aa
Immediate neighbours	tuaC, tuaA/1
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

• Locus tag: BSU35600

Phenotypes of a mutant

• slow growth PubMed
• severe cell shape defect PubMed

Database entries

• BsubCyc: BSU35600

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: MOP exporter family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU35600

• Structure:

• UniProt: O32273

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: tuaA-tuaB-tuaC-tuaD-tuaE-tuaF-tuaG-tuaH PubMed

• Expression browser: tuaB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of phosphate limitation (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Alexander J Meeske, Lok-To Sham, Harvey Kimsey, Byoung-Mo Koo, Carol A Gross, Thomas G Bernhardt, David Z Rudner
MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2015, 112(20);6437-42
[PubMed:25918422] [WorldCat.org] [DOI] (I p)

Rikki N Hvorup, Brit Winnen, Abraham B Chang, Yong Jiang, Xiao-Feng Zhou, Milton H Saier
The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily.
Eur J Biochem: 2003, 270(5);799-813
[PubMed:12603313] [WorldCat.org] [DOI] (P p)

Maryam Lahooti, Colin R Harwood
Transcriptional analysis of the Bacillus subtilis teichuronic acid operon.
Microbiology (Reading): 1999, 145 ( Pt 12);3409-3417
[PubMed:10627039] [WorldCat.org] [DOI] (P p)

B Soldo, V Lazarevic, M Pagni, D Karamata
Teichuronic acid operon of Bacillus subtilis 168.
Mol Microbiol: 1999, 31(3);795-805
[PubMed:10048024] [WorldCat.org] [DOI] (P p)

Wei Liu, F Marion Hulett
Comparison of PhoP binding to the tuaA promoter with PhoP binding to other Pho-regulon promoters establishes a Bacillus subtilis Pho core binding site.
Microbiology (Reading): 1998, 144 ( Pt 5);1443-1450
[PubMed:9611818] [WorldCat.org] [DOI] (P p)