YybP
- Description: membrane protein, may be involved in manganese detoxification
| Gene name | yybP |
| Synonyms | |
| Essential | no |
| Product | unknown |
| Function | unknown |
| Gene expression levels in SubtiExpress: yybP | |
| MW, pI | 15 kDa, 4.24 |
| Gene length, protein length | 444 bp, 148 aa |
| Immediate neighbours | ppaC, yybO |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
membrane proteins, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40560
Phenotypes of a mutant
Database entries
- BsubCyc: BSU40560
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cell membrane (according to Swiss-Prot)
Database entries
- BsubCyc: BSU40560
- Structure:
- UniProt: P37488
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: yybP PubMed
- Regulation:
- induced in the presence of Mn2+ (yybP-ykoY motif) PubMed
- Regulatory mechanism:
- yybP-ykoY motif, riboswitch, antitermination in the presence of the ligand Mn2+ PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ian R Price, Ahmed Gaballa, Fang Ding, John D Helmann, Ailong Ke
Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches.
Mol Cell: 2015, 57(6);1110-1123
[PubMed:25794619]
[WorldCat.org]
[DOI]
(I p)
Michael Dambach, Melissa Sandoval, Taylor B Updegrove, Vivek Anantharaman, L Aravind, Lauren S Waters, Gisela Storz
The ubiquitous yybP-ykoY riboswitch is a manganese-responsive regulatory element.
Mol Cell: 2015, 57(6);1099-1109
[PubMed:25794618]
[WorldCat.org]
[DOI]
(I p)
Jeffrey E Barrick, Keith A Corbino, Wade C Winkler, Ali Nahvi, Maumita Mandal, Jennifer Collins, Mark Lee, Adam Roth, Narasimhan Sudarsan, Inbal Jona, J Kenneth Wickiser, Ronald R Breaker
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control.
Proc Natl Acad Sci U S A: 2004, 101(17);6421-6
[PubMed:15096624]
[WorldCat.org]
[DOI]
(P p)
