YxkO

• Description: ADP/ATP-dependent NAD(P)H-hydrate dehydratase, general stress protein, survival of ethanol stress
  
  

Gene name	yxkO
Synonyms
Essential	no
Product	ADP/ATP-dependent NAD(P)H-hydrate dehydratase
Function	survival of ethanol stress
Gene expression levels in SubtiExpress: yxkO
MW, pI	29 kDa, 5.488
Gene length, protein length	828 bp, 276 aa
Immediate neighbours	yxlA, cydD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

general stress proteins (controlled by SigB)

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU38720

Database entries

• BsubCyc: BSU38720

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU38720

• Structure: 1KYH

• UniProt: P94368

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yxkO PubMed

• Expression browser: yxkO PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Miroslava Petrovova, Jan Tkadlec, Lukas Dvoracek, Eliska Streitova, Irena Licha
NAD(P)H-hydrate dehydratase- a metabolic repair enzyme and its role in Bacillus subtilis stress adaptation.
PLoS One: 2014, 9(11);e112590
[PubMed:25393291] [WorldCat.org] [DOI] (I e)

Igor A Shumilin, Marcin Cymborowski, Olga Chertihin, Kula N Jha, John C Herr, Scott A Lesley, Andrzej Joachimiak, Wladek Minor
Identification of unknown protein function using metabolite cocktail screening.
Structure: 2012, 20(10);1715-25
[PubMed:22940582] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

R-g Zhang, J Grembecka, E Vinokour, F Collart, I Dementieva, W Minor, A Joachimiak
Structure of Bacillus subtilis YXKO--a member of the UPF0031 family and a putative kinase.
J Struct Biol: 2002, 139(3);161-70
[PubMed:12457846] [WorldCat.org] [DOI] (P p)

Ken-Ichi Yoshida, Izumi Ishio, Eishi Nagakawa, Yoshiyuki Yamamoto, Mami Yamamoto, Yasutaro Fujita
Systematic study of gene expression and transcription organization in the gntZ-ywaA region of the Bacillus subtilis genome.
Microbiology (Reading): 2000, 146 ( Pt 3);573-579
[PubMed:10746760] [WorldCat.org] [DOI] (P p)