HemE

• Description: uroporphyrinogen decarboxylase (uroporphyrinogen III)
  
  

Gene name	hemE
Synonyms
Essential	no
Product	uroporphyrinogen decarboxylase (uroporphyrinogen III)
Function	heme biosynthesis
Gene expression levels in SubtiExpress: hemE
Metabolic function and regulation of this protein in SubtiPathways: HemE
MW, pI	39 kDa, 5.262
Gene length, protein length	1059 bp, 353 aa
Immediate neighbours	pbpF, hemH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU10120

Database entries

• BsubCyc: BSU10120

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Uroporphyrinogen III = coproporphyrinogen + 4 CO₂ (according to Swiss-Prot)

• Protein family: uroporphyrinogen decarboxylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU10120

• Structure: 2INF

• UniProt: P32395

• KEGG entry: [3]

• E.C. number: 4.1.1.37

Expression and regulation

• Operon: hemE-hemH-hemY PubMed

• Expression browser: hemE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jun Fan, Qun Liu, Quan Hao, Maikun Teng, Liwen Niu
Crystal structure of uroporphyrinogen decarboxylase from Bacillus subtilis.
J Bacteriol: 2007, 189(9);3573-80
[PubMed:17122346] [WorldCat.org] [DOI] (P p)

M Hansson, L Hederstedt
Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.
J Bacteriol: 1992, 174(24);8081-93
[PubMed:1459957] [WorldCat.org] [DOI] (P p)