ValS

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  • Description: valyl-tRNA synthetase

Gene name valS
Synonyms
Essential yes PubMed
Product valyl-tRNA synthetase
Function translation
Gene expression levels in SubtiExpress: valS
Metabolic function and regulation of this protein in SubtiPathways:
valS
MW, pI 101 kDa, 4.868
Gene length, protein length 2640 bp, 880 aa
Immediate neighbours folC, yszA
Sequences Protein DNA DNA_with_flanks
Genetic context
ValS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ValS expression.png















Categories containing this gene/protein

translation, essential genes, most abundant proteins

This gene is a member of the following regulons

T-box, Efp-dependent proteins

The gene

Basic information

  • Locus tag: BSU28090

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val) (according to Swiss-Prot)
  • Protein family: ValS type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 1IYW (from Thermus thermophilus, 41% identity, 60% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications

Christine Eymann, Annette Dreisbach, Dirk Albrecht, Jörg Bernhardt, Dörte Becher, Sandy Gentner, Le Thi Tam, Knut Büttner, Gerrit Buurman, Christian Scharf, Simone Venz, Uwe Völker, Michael Hecker
A comprehensive proteome map of growing Bacillus subtilis cells.
Proteomics: 2004, 4(10);2849-76
[PubMed:15378759] [WorldCat.org] [DOI] (P p)

D Luo, J Leautey, M Grunberg-Manago, H Putzer
Structure and regulation of expression of the Bacillus subtilis valyl-tRNA synthetase gene.
J Bacteriol: 1997, 179(8);2472-8
[PubMed:9098041] [WorldCat.org] [DOI] (P p)