KtrB

• Description: high affinity potassium transporter KtrA-KtrB, integral membrane subunit
  
  

Gene name	ktrB
Synonyms	yubG
Essential	no
Product	high affinity potassium transporter KtrA-KtrB, integral membrane subunit (proton symport)
Function	potassium uptake
Gene expression levels in SubtiExpress: ktrB
Interactions involving this protein in SubtInteract: KtrB
Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, ktrB
MW, pI	48 kDa, 10.116
Gene length, protein length	1335 bp, 445 aa
Immediate neighbours	ktrA, yubF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), coping with hyper-osmotic stress, membrane proteins

This gene is a member of the following regulons

YdaO riboswitch

The gene

Basic information

• Locus tag: BSU31100

Database entries

• BsubCyc: BSU31100

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): KtrD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • KtrB forms dimers PubMed
  • KtrA-KtrB PubMed, composed of an octameric KtrA ring and two KtrB dimers PubMed

• Localization: integral membrane protein PubMed

Database entries

• BsubCyc: BSU31100

• Structure:
  • 4J7C (the KtrA-KtrB complex) PubMed

• UniProt: O32081

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ktrA-ktrB PubMed

• Expression browser: ktrB PubMed

• Sigma factor:

• Regulation:
• Regulation:

• Regulatory mechanism:
  • expression is controlled via termination antitermination by the ydaO riboswitch, expression is switched off upon binding od c-di-AMP PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A954 ( ktrB::kan), PubMed, available at BGSC
  • GHB1 (D(ktrA-ktrB)::aphA3), available in Erhard Bremer's lab
  • GP92 (D(ktrA-ktrB)::aphA3), available in Jörg Stülke's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Erhard Bremer, University of Marburg, Germany homepage