FabG

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  • Description: beta-ketoacyl-acyl carrier protein reductase

Gene name fabG
Synonyms ylpF
Essential yes PubMed
Product beta-ketoacyl-acyl carrier protein reductase
Function fatty acid biosynthesis
Gene expression levels in SubtiExpress: fabG
Metabolic function and regulation of this protein in SubtiPathways:
fabG
MW, pI 26 kDa, 8.091
Gene length, protein length 738 bp, 246 aa
Immediate neighbours fabD, acpA
Sequences Protein DNA DNA_with_flanks
Genetic context
FabG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FabG expression.png




























Categories containing this gene/protein

biosynthesis of lipids, essential genes

This gene is a member of the following regulons

ComA regulon, FapR regulon

The gene

Basic information

  • Locus tag: BSU15910

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH (according to Swiss-Prot)
  • Protein family: short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1I01 (the enzyme from E. coli) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced if the cells experience an accumulation of malonyl-CoA (FapR) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications