CsbB

• Description: putative bactoprenol glycosyltransferase, general stress protein, required for protection against paraquat stress
  
  

Gene name	csbB
Synonyms	yfhN
Product	putative bactoprenol glycosyltransferase
Function	survival of stress conditions
Gene expression levels in SubtiExpress: csbB
MW, pI	37 kDa, 9.199
Gene length, protein length	987 bp, 329 aa
Immediate neighbours	yfhM, yfhO
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, V, W, X, Y), resistance against oxidative and electrophile stress, membrane proteins

This gene is a member of the following regulons

SigB regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU08600

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Additional information

• expression of CsbB in the absence of YfhO causes constitutive activation of SigM PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: GtrB subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: Q45539

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: csbB PubMed

• Expression browser: csbB PubMed

• Sigma factor: SigB PubMed, SigX PubMed

• Regulation: induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Hiromi Inoue, Daisuke Suzuki, Kei Asai
A putative bactoprenol glycosyltransferase, CsbB, in Bacillus subtilis activates SigM in the absence of co-transcribed YfhO.
Biochem Biophys Res Commun: 2013, 436(1);6-11
[PubMed:23632331] [WorldCat.org] [DOI] (I p)

Alexander Reder, Dirk Höper, Ulf Gerth, Michael Hecker
Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3601-10
[PubMed:22582280] [WorldCat.org] [DOI] (I p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

X Huang, J D Helmann
Identification of target promoters for the Bacillus subtilis sigma X factor using a consensus-directed search.
J Mol Biol: 1998, 279(1);165-73
[PubMed:9636707] [WorldCat.org] [DOI] (P p)

S Akbar, C W Price
Isolation and characterization of csbB, a gene controlled by Bacillus subtilis general stress transcription factor sigma B.
Gene: 1996, 177(1-2);123-8
[PubMed:8921856] [WorldCat.org] [DOI] (P p)