DltB

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  • Description: D-alanine transfer from Dcp to undecaprenol-phosphate, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Gene name dltB
Synonyms ipa-4r
Essential no
Product D-alanine transfer from Dcp to undecaprenol-phosphate
Function biosynthesis of teichoic acid

acid (D-alanyl transfer from Dcp to undecaprenol-phosphate)

Gene expression levels in SubtiExpress: dltB

acid (D-alanyl transfer from Dcp to undecaprenol-phosphate)

MW, pI 46 kDa, 9.944
Gene length, protein length 1185 bp, 395 aa
Immediate neighbours dltA, dltC
Sequences Protein DNA DNA_with_flanks
Genetic context
DltB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DltB expression.png
























Categories containing this gene/protein

cell wall synthesis, transporters/ other, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

SigD regulon, SigM regulon, SigX regulon, Spo0A regulon, stringent response, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU38510

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: membrane-bound acyltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • expression is reduced in a SigV mutant PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Min Cao, John D Helmann
The Bacillus subtilis extracytoplasmic-function sigmaX factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides.
J Bacteriol: 2004, 186(4);1136-46
[PubMed:14762009] [WorldCat.org] [DOI] (P p)

K Stephenson, C L Jensen, S T Jørgensen, C R Harwood
Simultaneous inactivation of the wprA and dltB genes of Bacillus subtilis reduces the yield of alpha-amylase.
Lett Appl Microbiol: 2002, 34(6);394-7
[PubMed:12028417] [WorldCat.org] [DOI] (P p)

M Perego, P Glaser, A Minutello, M A Strauch, K Leopold, W Fischer
Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.
J Biol Chem: 1995, 270(26);15598-606
[PubMed:7797557] [WorldCat.org] [DOI] (P p)