CssS

• Description: two-component sensor kinase, control of cellular responses to protein secretion stress
  
  

Gene name	cssS
Synonyms	yvqB
Essential	no
Product	two-component sensor kinase
Function	control of cellular responses to protein secretion stress
Gene expression levels in SubtiExpress: cssS
Interactions involving this protein in SubtInteract: CssS
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	51 kDa, 5.795
Gene length, protein length	1353 bp, 451 aa
Immediate neighbours	cssR, yirB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein modification, transcription factors and their control, heat shock proteins, membrane proteins, phosphoproteins

This gene is a member of the following regulons

CssR regulon

The gene

Basic information

• Locus tag: BSU33020

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of CssR

• Protein family:

• Paralogous protein(s):YkoH, KinE, YclK, YvrG

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:
  • the extracellular loop domain is required for signal perception PubMed

• Interactions:
  • CssS is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed
  • CssS-CssR

• Localization:
  • cell membrane (according to Swiss-Prot)
  • localized primarily at the division septum but also found in a punctate pattern with lower intensity throughout the cell cylinder PubMed

Database entries

• Structure:

• UniProt: O32193

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cssR-cssS PubMed

• Expression browser: cssS PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of secretion stress (CssR) PubMed

• Regulatory mechanism:
  • CssR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: