RsbQ

• Description: alpha/beta hydrolase, required for RsbP activation
  
  

Gene name	rsbQ
Synonyms	yvfQ
Essential	no
Product	alpha/beta hydrolase
Function	control of SigB activity
Gene expression levels in SubtiExpress: rsbQ
Interactions involving this protein in SubtInteract: RsbQ
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	29 kDa, 5
Gene length, protein length	807 bp, 269 aa
Immediate neighbours	yvfR, rsbP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control

The gene

Basic information

• Locus tag: BSU34100

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: AB hydrolase superfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsbQ-RsbP PubMed

• Localization:

Database entries

• Structure: 1WOM PubMed

• UniProt: O07015

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: rsbQ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Chet Price, Davis, USA homepage

References

Additional publications: PubMed

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936

Margaret S Brody, Valley Stewart, Chester W Price
Bypass suppression analysis maps the signalling pathway within a multidomain protein: the RsbP energy stress phosphatase 2C from Bacillus subtilis.
Mol Microbiol: 2009, 72(5);1221-34
[PubMed:19432806] [WorldCat.org] [DOI] (I p)

Tomonori Kaneko, Nobuo Tanaka, Takashi Kumasaka
Crystal structures of RsbQ, a stress-response regulator in Bacillus subtilis.
Protein Sci: 2005, 14(2);558-65
[PubMed:15632289] [WorldCat.org] [DOI] (P p)

M S Brody, K Vijay, C W Price
Catalytic function of an alpha/beta hydrolase is required for energy stress activation of the sigma(B) transcription factor in Bacillus subtilis.
J Bacteriol: 2001, 183(21);6422-8
[PubMed:11591687] [WorldCat.org] [DOI] (P p)