Smc

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  • Description: chromosome condensation and segregation SMC protein

Gene name smc
Synonyms ylqA
Essential yes PubMed
Product chromosome condensation and segregation SMC protein
Function structural maintenance of the chromosome
Gene expression levels in SubtiExpress: smc
Interactions involving this protein in SubtInteract: Smc
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 135 kDa, 5.266
Gene length, protein length 3558 bp, 1186 aa
Immediate neighbours rnc, ftsY
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Smc context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Smc expression.png















Categories containing this gene/protein

DNA condensation/ segregation, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU15940

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: SMC family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
    • 3ZGX (complex between the head domain of Smc (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of ScpA) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Peter L Graumann, Tobias Knust
Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair.
Chromosome Res: 2009, 17(2);265-75
[PubMed:19308706] [WorldCat.org] [DOI] (I p)

Christine Kaimer, Peter L Graumann
Players between the worlds: multifunctional DNA translocases.
Curr Opin Microbiol: 2011, 14(6);719-25
[PubMed:22047950] [WorldCat.org] [DOI] (I p)


Original publications

Additional publications: PubMed