RlmCD

• Description: rRNA methyltransferase
  
  

Gene name	rlmCD
Synonyms	yerS, yefA
Essential	no
Product	rRNA methyltransferase
Function	23S rRNA maturation
Gene expression levels in SubtiExpress: rlmCD
MW, pI	51 kDa, 5.707
Gene length, protein length	1377 bp, 459 aa
Immediate neighbours	dgkB, yefB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation

The gene

Basic information

• Locus tag: BSU06730

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: methylation of U747 and U1939 in 23S rRNA PubMed

• Protein family: COG2265

• Paralogous protein(s): YfjO

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31503

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: rlmCD PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Benoit Desmolaize, Céline Fabret, Damien Brégeon, Simon Rose, Henri Grosjean, Stephen Douthwaite
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA.
Nucleic Acids Res: 2011, 39(21);9368-75
[PubMed:21824914] [WorldCat.org] [DOI] (I p)