HemB

From SubtiWiki
Revision as of 14:32, 7 August 2012 by 134.76.70.252 (talk)
Jump to: navigation, search
  • Description: porphobilinogen synthase

Gene name hemB
Synonyms
Essential no
Product porphobilinogen synthase
Function heme biosynthesis
Gene expression levels in SubtiExpress: hemB
MW, pI 36 kDa, 4.98
Gene length, protein length 972 bp, 324 aa
Immediate neighbours hemL, hemD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HemB expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, phosphoproteins

This gene is a member of the following regulons

PerR regulon

The gene

Basic information

  • Locus tag: BSU28130

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 5-aminolevulinate = porphobilinogen + 2 H2O (according to Swiss-Prot)
  • Protein family: ALADH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylated on Arg-217 PubMed
  • Cofactor(s): zinc
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References