GcvPB

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  • Description: glycine decarboxylase (subunit 2)

Gene name gcvPB
Synonyms yqhK, gcvP
Essential no
Product glycine decarboxylase (subunit 2)
Function glycine utilization
Gene expression levels in SubtiExpress: gcvPB
MW, pI 54 kDa, 5.283
Gene length, protein length 1464 bp, 488 aa
Immediate neighbours yqhL, gcvPA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GcvPB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GcvPB expression.png
























Categories containing this gene/protein

utilization of amino acids, membrane proteins

This gene is a member of the following regulons

Gly-box

The gene

Basic information

  • Locus tag: BSU24550

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2 (according to Swiss-Prot)
  • Protein family: C-terminal subunit subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: repressed by casamino acids PubMed , induced by glycine PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Maumita Mandal, Mark Lee, Jeffrey E Barrick, Zasha Weinberg, Gail Mitchell Emilsson, Walter L Ruzzo, Ronald R Breaker
A glycine-dependent riboswitch that uses cooperative binding to control gene expression.
Science: 2004, 306(5694);275-9
[PubMed:15472076] [WorldCat.org] [DOI] (I p)

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)