YhcS

Gene name	yhcS
Synonyms
Essential	no
Product	sortase
Function	anchoring of proteins to the cell wall
Gene expression levels in SubtiExpress: yhcS
Interactions involving this protein in SubtInteract: YhcS
MW, pI	21 kDa, 7.169
Gene length, protein length	594 bp, 198 aa
Immediate neighbours	yhcR, yhcT
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

The gene

Basic information

• Locus tag: BSU09200

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: C-terminal anchoring of proteins to the cell wall

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YhcS-YhcR PubMed, YhcS-YfkN PubMed (substrates of YhcS)

• Localization: membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P54603

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yhcS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Thomas Spirig, Ethan M Weiner, Robert T Clubb
Sortase enzymes in Gram-positive bacteria.
Mol Microbiol: 2011, 82(5);1044-59
[PubMed:22026821] [WorldCat.org] [DOI] (I p)

Original publications

Additional referencecs: PubMed

Hamidreza Fasehee, Helga Westers, Albert Bolhuis, Haike Antelmann, Michael Hecker, Wim J Quax, Agha F Mirlohi, Jan Maareten van Dijl, Gholamreza Ahmadian
Functional analysis of the sortase YhcS in Bacillus subtilis.
Proteomics: 2011, 11(19);3905-13
[PubMed:21800427] [WorldCat.org] [DOI] (I p)