CzrA

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  • Description: transcriptional repressor of cadA and czcD

Gene name czrA
Synonyms yozA
Essential no
Product transcriptional repressor (ArsR family)
Function regulation of resistance against toxic metal cations
Metabolic function and regulation of this protein in SubtiPathways:
metal ion homeostasis
MW, pI 12 kDa, 5.719
Gene length, protein length 321 bp, 107 aa
Immediate neighbours yobW, yocA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YozA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

The CzrA regulon:

The gene

Basic information

  • Locus tag: BSU19120

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Expression

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • DNA-binding activity of CzrA is inactivated by high concentrations of toxic metal ions (induction)

Database entries

  • Structure:
    • 1R1U (the apo-repressor from Staph. aureus, 49% identity, 82% similarity) PubMed
    • 1R1V (the Zn(II) form from Staph. aureus, 49% identity, 82% similarity) PubMed
    • 2KJB (the DNA-bound form from Staph. aureus, 49% identity, 82% similarity) PubMed
  • UniProt: O31844
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed