SecG

• Description: preprotein translocase subunit
  
  

Gene name	secG
Synonyms	yvaL
Essential	no
Product	preprotein translocase subunit
Function	protein secretion
Interactions involving this protein in SubtInteract: SecG
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	7 kDa, 10.413
Gene length, protein length	228 bp, 76 aa
Immediate neighbours	yvaK, yvaM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

protein secretion, membrane proteins

The gene

Basic information

• Locus tag: BSU33630

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Additional information

Deletion of secG from the chromosome causes a temperature sensitive secretion defect. PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: secG family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (SecY-SecE-SecG)2-SecA2 PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 3DL8 (structure of the (SecY-SecE-SecG)-SecA complex) PubMed

• UniProt: O32233

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: secG-yvaK-rnr-smpB-ssrA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jochen Zimmer, Yunsun Nam, Tom A Rapoport
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature: 2008, 455(7215);936-43
[PubMed:18923516] [WorldCat.org] [DOI] (I p)

Ji-Hyun Shin, Chester W Price
The SsrA-SmpB ribosome rescue system is important for growth of Bacillus subtilis at low and high temperatures.
J Bacteriol: 2007, 189(10);3729-37
[PubMed:17369301] [WorldCat.org] [DOI] (P p)

K H van Wely, J Swaving, C P Broekhuizen, M Rose, W J Quax, A J Driessen
Functional identification of the product of the Bacillus subtilis yvaL gene as a SecG homologue.
J Bacteriol: 1999, 181(6);1786-92
[PubMed:10074070] [WorldCat.org] [DOI] (P p)