LicC

• Description: lichenan-specific phosphotransferase system, EIIC component of the PTS
  
  

Gene name	licC
Synonyms	celB
Essential	no
Product	lichenan-specific phosphotransferase system, EIIC component
Function	lichenan uptake and phosphorylation
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	48 kDa, 8.584
Gene length, protein length	1356 bp, 452 aa
Immediate neighbours	licA, licB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, membrane proteins

This gene is a member of the following regulons

CcpA regulon, LicR regulon

The gene

Basic information

• Locus tag: BSU38580

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: PTS permease, lactose permease (Lac) family PubMed

• Paralogous protein(s): YwbA, GmuC

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: LicB-LicC

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 3QNQ (EIIC component of diacetylchitobiose specific PTS from Bacillus cereus; 60% identity, 87% similarity) PubMed

• UniProt: P46317

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: licB-licC-licA-licH PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • carbon catabolite repression (CcpA) PubMed
  • induction by oligomeric ß-glucosides (LicR)PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • LicR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed