CadA
- Description: cadmium transporting ATPase, resistance to cadmium
Gene name | cadA |
Synonyms | yvgW |
Essential | no |
Product | cadmium transporting ATPase |
Function | cadmium export |
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis | |
MW, pI | 75 kDa, 5.998 |
Gene length, protein length | 2106 bp, 702 aa |
Immediate neighbours | bdbD, copA |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
transporters/ other, resistance against toxic metals, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU33490
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out) (according to Swiss-Prot)
- Protein family: Type IB subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O32219
- KEGG entry: [2]
- E.C. number: 3.6.3.3
Additional information
Expression and regulation
- Operon: cadA PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947]
[WorldCat.org]
[DOI]
(P p)
Ahmed Gaballa, John D Helmann
Bacillus subtilis CPx-type ATPases: characterization of Cd, Zn, Co and Cu efflux systems.
Biometals: 2003, 16(4);497-505
[PubMed:12779235]
[WorldCat.org]
[DOI]
(P p)
I M Solovieva, K D Entian
Investigation of the yvgW Bacillus subtilis chromosomal gene involved in Cd(2+) ion resistance.
FEMS Microbiol Lett: 2002, 208(1);105-9
[PubMed:11934502]
[WorldCat.org]
[DOI]
(P p)