Mta

• Description: transcriptional activator of multidrug-efflux transporter genes, activates ymfD expression
  
  

Gene name	mta
Synonyms	ywnD
Essential	no
Product	transcriptional activator
Function	regulation of multidrug-efflux transporter genes
MW, pI	29 kDa, 4.949
Gene length, protein length	771 bp, 257 aa
Immediate neighbours	clsA, ywnC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

Mta regulon

The gene

Basic information

• Locus tag: BSU36600

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1JBG (N-terminal domain), 1R8D (complex of N-terminal domain with DNA)

• UniProt: P71039

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mta PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • positive autoregulation PubMed

• Regulatory mechanism:
  • Mta: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Richard Brennan, Houston, Texas, USA Homepage