YtxJ

• Description: general stress protein
  
  

Gene name	ytxJ
Synonyms	csb40
Essential	no
Product	unknown
Function	unknown
MW, pI	12 kDa, 5.089
Gene length, protein length	324 bp, 108 aa
Immediate neighbours	aroA, ytxH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU29760

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Trx family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: contains a single conserved Cys residue in a motif (TCPIS) reminiscent of that found in monothiol glutaredoxins [3]

• Modification: phosphorylation on (Thr-93 OR Ser-94 OR Ser-96 OR Thr-99) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39914

• KEGG entry: [4]

• E.C. number:

Expression and regulation

• Operon: ytxG-ytxH-ytxJ PubMed

• Sigma factor: SigB PubMed, SigH PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Your additional remarks

YpdA, YqiW, Yphp and YtxJ cooccur in those species predicted to synthesize bacillithiol.

References

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)

D Varón, M S Brody, C W Price
Bacillus subtilis operon under the dual control of the general stress transcription factor sigma B and the sporulation transcription factor sigma H.
Mol Microbiol: 1996, 20(2);339-50
[PubMed:8733232] [WorldCat.org] [DOI] (P p)