YtrA

• Description: transcriptional repressor of the ytrA-ytrB-ytrC-ytrD-ytrE-ytrF operon, GntR family
  
  

Gene name	ytrA
Synonyms
Essential	no
Product	transcriptional repressor (GntR family)
Function	regulation of acetoine uptake
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	14 kDa, 8.094
Gene length, protein length	390 bp, 130 aa
Immediate neighbours	ytrB, ytzC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU30460

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3NEU (similar protein from Listeria innocua, 41% identity)

• UniProt: O34712

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytrA-ytrB-ytrC-ytrD-ytrE-ytrF PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed early in the stationary phase PubMed
  • induced by cold shock (5-fold) PubMed

• Regulatory mechanism:
  • YtrA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Carsten L Beckering, Leif Steil, Michael H W Weber, Uwe Völker, Mohamed A Marahiel
Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis.
J Bacteriol: 2002, 184(22);6395-402
[PubMed:12399512] [WorldCat.org] [DOI] (P p)

K I Yoshida, Y Fujita, S D Ehrlich
An operon for a putative ATP-binding cassette transport system involved in acetoin utilization of Bacillus subtilis.
J Bacteriol: 2000, 182(19);5454-61
[PubMed:10986249] [WorldCat.org] [DOI] (P p)