Noc

• Description: DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division
  
  

Gene name	noc
Synonyms	yyaA
Essential	no
Product	effector of nucleoid occlusion
Function	control of cell division
MW, pI	32 kDa, 5.812
Gene length, protein length	849 bp, 283 aa
Immediate neighbours	yyaB, rsmG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40990

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds specific sites on the chromosome PubMed

• Protein family: ParB family (according to Swiss-Prot)

• Paralogous protein(s): Spo0J

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P37524

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: thdF-gidA-rsmG-noc PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion: available in the Jeff Errington lab

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jeff Errington, Newcastle, UK Homepage

References

Reviews

Marc Bramkamp, Suey van Baarle
Division site selection in rod-shaped bacteria.
Curr Opin Microbiol: 2009, 12(6);683-8
[PubMed:19884039] [WorldCat.org] [DOI] (I p)

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)