Difference between revisions of "TrpE"
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=The gene= | =The gene= | ||
Revision as of 07:22, 23 June 2009
- Description: anthranilate synthase (subunit I)
| Gene name | trpE |
| Synonyms | |
| Essential | no |
| Product | anthranilate synthase (subunit I) |
| Function | biosynthesis of tryptophan |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 57 kDa, 5.246 |
| Gene length, protein length | 1545 bp, 515 aa |
| Immediate neighbours | trpD, aroH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU22680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: subject to feedback inhibition by tryptophan PubMed
- Localization:
Database entries
- Structure:
- Swiss prot entry: P03963
- KEGG entry: [3]
- E.C. number: 4.1.3.27
Additional information
Expression and regulation
- Regulatory mechanism: TRAP: binding to the mRNA in the presence of tryptophan, this results in transcription termination PubMed
- Additional information: subject to feedback inhibition by tryptophan PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
