CcpA

• Description: carbon catabolite control protein A, involved in glucose regulation of many genes; mediates carbon catabolite repression (CCR)of catabolic genes and the positive regulation of genes involved in excretion of excess carbon
  
  

Gene name	ccpA
Synonyms	graR, alsA, amyR
Essential	no
Product	transcriptional regulator
Function	mediates carbon catabolite repression (CCR)
MW, pI	36,8 kDa, 5.06
Gene length, protein length	1002 bp, 334 amino acids
Immediate neighbours	aroA, motP
Gene sequence (+200bp)	Protein sequence
Genetic context File:GenE context.gif

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcriptional regulator of carbon catabolite repression (CCR)

• Protein family: LacI family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • HTH lacI-type Domain (1 – 58)
  • DNA binding Domain (6 – 25)

• Modification:

• Cofactor(s): HPr-Ser46-P, Crh-Ser-46-P

• Effectors of protein activity:glucose-6-phosphate, fructose-1,6-bisphosphate Pubmed

• Interactions: CcpA-PtsH PubMed, CcpA-Crh PubMed

• Localization:

Database entries

• Structure: CcpA-Crh-DNA-complex NCBI, complex with P-Ser-HPr and sulphate ions NCBI

• Swiss prot entry: [3]

• KEGG entry: [4]
• E.C. number:

Expression and regulation

• Operon: ccpA motPS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
2. Terahara et al. (2006) An intergenic stem-loop mutation in the Bacillus subtilis ccpA-motPS operon increases motPS transcription and the MotPS contribution to motility J Bacteriol. 188(7): 2701-5. PubMed