Difference between revisions of "MsrA"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[msrA]]-[[msrB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18662407 PubMed] |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18662407 PubMed] |
| − | * '''Regulation:''' | + | * '''Regulation:''' induced by oxidative stress ([[Spx]]) |
| − | * '''Regulatory mechanism:''' | + | * '''Regulatory mechanism:''' Spx: oxidized Spx binds [[RpoA]] and enhances ''[[msrA]]-[[msrB]]'' operon transcription [http://www.ncbi.nlm.nih.gov/sites/entrez/18662407 PubMed] |
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 06:43, 28 May 2009
- Description: peptide methionine sulfoxide reductase
| Gene name | msrA |
| Synonyms | yppP |
| Essential | no |
| Product | peptide methionine sulfoxide reductase |
| Function | regeneration of methionine and restoration of protein function after oxidative damage |
| MW, pI | 20 kDa, 5.709 |
| Gene length, protein length | 531 bp, 177 aa |
| Immediate neighbours | msrB, ypoP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P54154
- KEGG entry: BSU21690
- E.C. number: 1.8.4.11
Additional information
Expression and regulation
- Regulation: induced by oxidative stress (Spx)
- Regulatory mechanism: Spx: oxidized Spx binds RpoA and enhances msrA-msrB operon transcription PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
