Protein secretion

Parent categories	3. Information processing 3.3. Protein synthesis, modification and degradation
Neighbouring categories	3.3.1. Translation 3.3.2. Chaperones/ protein folding 3.3.3. Protein modification 3.3.4. Protein secretion 3.3.5. Proteolysis
Related categories	signal recognition particle
Overview on the categories (Excel file) All genes and their categories (Excel file)

Genes in this functional category

• comC
• csaA
• ecsA
• ecsB
• ffh
• fliP
• fliQ
• fliR
• fliZ
• flhA
• flhB
• ftsY
• lspA
• mstX
• prsA
• rnc
• scr
• secA
• secDF
• secE
• secG
• secY
• sipS
• sipT
• sipU
• sipV
• sipW
• spoIIIAB
• spoIIIAC
• spoIIIAD
• spoIIIAE
• spoIIIAF
• spoIIIAG
• spoIIIAH
• spoIIIJ
• sppA
• yhcS
• yidC2
• ylxM

• The TAT system
  • tatAC
  • tatAD
  • tatAY
  • tatCD
  • tatCY

• Type VII secretion system
  • yukB
  • yukC
  • yukD
  • yueB
  • yueC

Additional candidates (based on similarity)

• yacD
• yobE
• yoqW

Important reviews

• The structure of a Tat-dependent signal peptide (PhoD) can be found here: PubMed

Kelly M Frain, Colin Robinson, Jan Maarten van Dijl
Transport of Folded Proteins by the Tat System.
Protein J: 2019, 38(4);377-388
[PubMed:31401776] [WorldCat.org] [DOI] (I p)

Yaramah M Zalucki, Michael P Jennings
Signal peptidase I processed secretory signal sequences: Selection for and against specific amino acids at the second position of mature protein.
Biochem Biophys Res Commun: 2017, 483(3);972-977
[PubMed:28088521] [WorldCat.org] [DOI] (I p)

Alexandra Tsirigotaki, Jozefien De Geyter, Nikolina Šoštaric, Anastassios Economou, Spyridoula Karamanou
Protein export through the bacterial Sec pathway.
Nat Rev Microbiol: 2017, 15(1);21-36
[PubMed:27890920] [WorldCat.org] [DOI] (I p)

Vivianne J Goosens, Jan Maarten van Dijl
Twin-Arginine Protein Translocation.
Curr Top Microbiol Immunol: 2017, 404;69-94
[PubMed:27121927] [WorldCat.org] [DOI] (P p)

Kenneth Cline
Mechanistic Aspects of Folded Protein Transport by the Twin Arginine Translocase (Tat).
J Biol Chem: 2015, 290(27);16530-8
[PubMed:25975269] [WorldCat.org] [DOI] (I p)

Ben C Berks
The twin-arginine protein translocation pathway.
Annu Rev Biochem: 2015, 84;843-64
[PubMed:25494301] [WorldCat.org] [DOI] (I p)

Vivianne J Goosens, Carmine G Monteferrante, Jan Maarten van Dijl
The Tat system of Gram-positive bacteria.
Biochim Biophys Acta: 2014, 1843(8);1698-706
[PubMed:24140208] [WorldCat.org] [DOI] (P p)

Marco J Klein, Stephan L Grage, Claudia Muhle-Goll, Jochen Bürck, Sergii Afonin, Anne S Ulrich
Structure analysis of the membrane-bound PhoD signal peptide of the Tat translocase shows an N-terminal amphiphilic helix.
Biochim Biophys Acta: 2012, 1818(12);3025-31
[PubMed:22960285] [WorldCat.org] [DOI] (P p)

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)

Tracy Palmer, Ben C Berks
The twin-arginine translocation (Tat) protein export pathway.
Nat Rev Microbiol: 2012, 10(7);483-96
[PubMed:22683878] [WorldCat.org] [DOI] (I e)

Brian M Forster, Hélène Marquis
Protein transport across the cell wall of monoderm Gram-positive bacteria.
Mol Microbiol: 2012, 84(3);405-13
[PubMed:22471582] [WorldCat.org] [DOI] (I p)

Olaf Schneewind, Dominique M Missiakas
Protein secretion and surface display in Gram-positive bacteria.
Philos Trans R Soc Lond B Biol Sci: 2012, 367(1592);1123-39
[PubMed:22411983] [WorldCat.org] [DOI] (I p)

Gustavo A de Souza, Nils A Leversen, Hiwa Målen, Harald G Wiker
Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway.
J Proteomics: 2011, 75(2);502-10
[PubMed:21920479] [WorldCat.org] [DOI] (I p)

Roxane Simeone, Daria Bottai, Roland Brosch
ESX/type VII secretion systems and their role in host-pathogen interaction.
Curr Opin Microbiol: 2009, 12(1);4-10
[PubMed:19155186] [WorldCat.org] [DOI] (I p)

Colin R Harwood, Rocky Cranenburgh
Bacillus protein secretion: an unfolding story.
Trends Microbiol: 2008, 16(2);73-9
[PubMed:18182292] [WorldCat.org] [DOI] (P p)

Arnold J M Driessen, Nico Nouwen
Protein translocation across the bacterial cytoplasmic membrane.
Annu Rev Biochem: 2008, 77;643-67
[PubMed:18078384] [WorldCat.org] [DOI] (P p)

Girbe Buist, Anja N J A Ridder, Jan Kok, Oscar P Kuipers
Different subcellular locations of secretome components of Gram-positive bacteria.
Microbiology (Reading): 2006, 152(Pt 10);2867-2874
[PubMed:17005968] [WorldCat.org] [DOI] (P p)

Kunio Yamane, Keigo Bunai, Hiroshi Kakeshita
Protein traffic for secretion and related machinery of Bacillus subtilis.
Biosci Biotechnol Biochem: 2004, 68(10);2007-23
[PubMed:15502345] [WorldCat.org] [DOI] (P p)

Harold Tjalsma, Haike Antelmann, Jan D H Jongbloed, Peter G Braun, Elise Darmon, Ronald Dorenbos, Jean-Yves F Dubois, Helga Westers, Geeske Zanen, Wim J Quax, Oscar P Kuipers, Sierd Bron, Michael Hecker, Jan Maarten van Dijl
Proteomics of protein secretion by Bacillus subtilis: separating the "secrets" of the secretome.
Microbiol Mol Biol Rev: 2004, 68(2);207-33
[PubMed:15187182] [WorldCat.org] [DOI] (P p)

J de Keyzer, C van der Does, A J M Driessen
The bacterial translocase: a dynamic protein channel complex.
Cell Mol Life Sci: 2003, 60(10);2034-52
[PubMed:14618254] [WorldCat.org] [DOI] (P p)

Mark J Pallen
The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?
Trends Microbiol: 2002, 10(5);209-12
[PubMed:11973144] [WorldCat.org] [DOI] (P p)