Difference between revisions of "BsrG"
| Line 1: | Line 1: | ||
| − | * '''Description:''' hydrophobic toxin <br/><br/> | + | * '''Description:''' hydrophobic toxin; interferes with cell envelope biosynthesis, causes membrane |
| + | invaginations together with delocalization of the [[cell wall synthesis]] machinery, triggers | ||
| + | autolysis, and inhibits protein biosynthesis <br/><br/> | ||
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || toxin | + | |style="background:#ABCDEF;" align="center"| '''Product''' || class I toxin |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' ||unknown | |style="background:#ABCDEF;" align="center"|'''Function''' ||unknown | ||
| Line 129: | Line 131: | ||
=References= | =References= | ||
| − | <pubmed>18948176, 20525796 23969414 22229825</pubmed> | + | <pubmed>18948176, 20525796 23969414 22229825 26234942</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:14, 4 August 2015
- Description: hydrophobic toxin; interferes with cell envelope biosynthesis, causes membrane
invaginations together with delocalization of the cell wall synthesis machinery, triggers
autolysis, and inhibits protein biosynthesis
| Gene name | bsrG |
| Synonyms | |
| Essential | no |
| Product | class I toxin |
| Function | unknown |
| MW, pI | |
| Gene length, protein length | 294 bp, 38 aa |
| Immediate neighbours | yolA, SR4 |
| Get the DNA and protein | |
| Genetic context File:BsrG context.gif This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
toxins, antitoxins and immunity against toxins, SPß prophage, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- BsubCyc: ?
- DBTBS entry: no entry
- SubtiList entry: no entry
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- membrane protein (based on the presence of a trans-membrane domain) PubMed
Database entries
- BsubCyc: ?
- Structure:
- UniProt:
- KEGG entry:
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
- half-life of the mRNA: 15 min PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
Labs working on this gene/protein
Sabine Brantl, Jena, Germany
Your additional remarks
References
Natalie Jahn, Sabine Brantl, Henrik Strahl
Against the mainstream: the membrane-associated type I toxin BsrG from Bacillus subtilis interferes with cell envelope biosynthesis without increasing membrane permeability.
Mol Microbiol: 2015, 98(4);651-66
[PubMed:26234942]
[WorldCat.org]
[DOI]
(I p)
Natalie Jahn, Sabine Brantl
One antitoxin--two functions: SR4 controls toxin mRNA decay and translation.
Nucleic Acids Res: 2013, 41(21);9870-80
[PubMed:23969414]
[WorldCat.org]
[DOI]
(I p)
Natalie Jahn, Heike Preis, Christoph Wiedemann, Sabine Brantl
BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system.
Mol Microbiol: 2012, 83(3);579-98
[PubMed:22229825]
[WorldCat.org]
[DOI]
(I p)
Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796]
[WorldCat.org]
[DOI]
(I p)
Shinichi Saito, Hiroshi Kakeshita, Kouji Nakamura
Novel small RNA-encoding genes in the intergenic regions of Bacillus subtilis.
Gene: 2009, 428(1-2);2-8
[PubMed:18948176]
[WorldCat.org]
[DOI]
(P p)
