Difference between revisions of "PgpH"
(→References) |
|||
Line 144: | Line 144: | ||
=References= | =References= | ||
==Reviews== | ==Reviews== | ||
− | <pubmed>25637595</pubmed> | + | <pubmed>25637595 25869574 </pubmed> |
==Original publications== | ==Original publications== | ||
<pubmed>21630458 25583510 </pubmed> | <pubmed>21630458 25583510 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 15:54, 17 April 2015
- Description: c-di-AMP specific phosphodiesterase
Gene name | yqfF |
Synonyms | |
Essential | no |
Product | c-di-AMP specific phosphodiesterase |
Function | control of c-di-AMP homeostasis |
Gene expression levels in SubtiExpress: yqfF | |
MW, pI | 78 kDa, 7.697 |
Gene length, protein length | 2133 bp, 711 aa |
Immediate neighbours | yqfG, phoH |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
metabolism of signalling nucleotides, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU25330
Phenotypes of a mutant
Database entries
- BsubCyc: BSU25330
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- hydrolysis of c-di-AMP to 5'-pApA PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Cofactors: Mn(2+) PubMed
- Effectors of protein activity:
- ppGpp acts as allosteric inhibitor of phosphodiesterase activity (in Listeria monocytogenes) PubMed
- Interactions:
- YqfF is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed
- Localization:
- cell membrane PubMed (according to UniProt)
Database entries
- BsubCyc: BSU25330
- Structure:
- UniProt: P46344
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- SM-GN1 (yqfF-spc), available in Anne Galinier's and Boris Görke's labs
- BKE25330 (yqfF::erm without terminator, available in the BGSC and in Jörg Stülke's lab)
- GP2033 (yqfF::tet, available in Jörg Stülke's lab)
- GP2034 (yqfF::erm without terminator, available in Jörg Stülke's lab)
- GP2049 (yqfF::cat without terminator, available in Jörg Stülke's lab)
- Expression vector:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Fabian M Commichau, Achim Dickmanns, Jan Gundlach, Ralf Ficner, Jörg Stülke
A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.
Mol Microbiol: 2015, 97(2);189-204
[PubMed:25869574]
[WorldCat.org]
[DOI]
(I p)
John D Helmann
Chemical proteomics reveals a second family of cyclic-di-AMP hydrolases.
Proc Natl Acad Sci U S A: 2015, 112(7);1921-2
[PubMed:25637595]
[WorldCat.org]
[DOI]
(I p)
Original publications