Difference between revisions of "MciZ"
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[MciZ]]-[[FtsZ]] {{PubMed|18284588}} | + | ** [[MciZ]]-[[FtsZ]] {{PubMed|18284588}}, K<sub>D</sub>: 150 nM {{PubMed|25848052}} |
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
Revision as of 18:17, 9 April 2015
- Description: FtsZ inhibition peptide
| Gene name | mciZ |
| Synonyms | |
| Essential | no |
| Product | FtsZ inhibition peptide |
| Function | inhibits GTPase activity of FtsZ and Z ring formation during sporulation |
| Interactions involving this protein in SubtInteract: MciZ | |
| MW, pI | 4.8 kDa, y.yy |
| Gene length, protein length | 120 bp, 40 aa |
| Immediate neighbours | nudF, yqkF |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: no entry
Additional information
This gene was only recently identified. PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: inhibits GTPase activity of FtsZ and Z ring formation during sporulation PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Swiss prot entry:
- KEGG entry: no entry
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
Alexandre W Bisson-Filho, Karen F Discola, Patrícia Castellen, Valdir Blasios, Alexandre Martins, Maurício L Sforça, Wanius Garcia, Ana Carolina M Zeri, Harold P Erickson, Andréa Dessen, Frederico J Gueiros-Filho
FtsZ filament capping by MciZ, a developmental regulator of bacterial division.
Proc Natl Acad Sci U S A: 2015, 112(17);E2130-8
[PubMed:25848052]
[WorldCat.org]
[DOI]
(I p)
Aaron A Handler, Joo Eun Lim, Richard Losick
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);588-99
[PubMed:18284588]
[WorldCat.org]
[DOI]
(I p)
