cysL

cysL
168

transcriptional activator of the cysJ-cysI operon

Locus
BSU_37650
Molecular weight
34.04 kDa
Isoelectric point
6.96
Protein length
299 aaSequenceBlast
Gene length
900 bpSequenceBlast
Function
regulation of cysteine biosynthesis
Product
transcriptional regulator (LysR family)
Essential
no
Synonyms
cysL, ywfK, ipa-89d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0583 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,864,309 → 3,865,208
Phenotypes of a mutant
unable to grow with sulfate or sulfite as the only sulfur source PubMed
defective in biofilm formation PubMed
The protein
Protein family
LysR family (according to UniProt)
Domains
HTH lysR-type domain (aa 1-58) (according to UniProt)
Structure
5Y2V (PDB) (from Synechocystis sp., 31% identity) PubMed
P39647 (AlphaFold)
Expression and Regulation
Operons
Genes
cysL
Description
PubMed
Regulation
repressed by sulfate, sulfite, and thiosulfate (CysL) PubMed
Regulatory mechanism
CysL: auto-repression, PubMed, in cysL regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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cysL

2025-03-21 16:46:31

ghost

65

d8ca63431170d901e34b60000165fe22623caa2d

8411D3675BFFD6A9C51ACEB1D75DA0AEC8B014CB

Biological materials
Mutant
MGNA-B668 (ywfK::erm), available at the NBRP B. subtilis, Japan
BKE37650 (ΔcysL::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAAACCCCACCCCTGTCA,  downstream forward: _UP4_TGATATAATAGTTTTCGTTC
BKK37650 (ΔcysL::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAAACCCCACCCCTGTCA,  downstream forward: _UP4_TGATATAATAGTTTTCGTTC
References
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Page visits: 2969

Time of last update: 2025-03-29 23:56:48

Author of last update: Melvin.boenninger